The human microbiota in early life Initial colonization and development PhD Thesis
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چکیده
....................................................................................................................... III RESUME ............................................................................................................................ V TABLE OF CONTENT ...................................................................................................... VII TABLE OF FIGURES ........................................................................................................ IX ABBREVIATIONS ............................................................................................................. XI
منابع مشابه
Microbial Composition of the Initial Colonization of Newborns.
Early-life interaction with indigenous intestinal microbes is a prerequisite for healthy immune and metabolic maturation. Human infants acquire their gut microbiota predominantly from the mother. A considerable inoculum of microbes is received by the neonate during vaginal delivery. Recent observations suggest that human gut colonization may be initiated prenatally by microbes in amniotic fluid...
متن کاملImpact of the Gut Microbiota on Vaccine Responses
Non-responsiveness or poor responsiveness to vaccines are challenging issues in vaccine development, and efforts have been made to find out the potential reasons for these conditions. Intestinal microbiome plays a key role in regulating and development of immune system and the composition and diversity of microbiota in different individuals on the one hand, and the imbalance of intestinal micro...
متن کاملGenome-resolved metaproteomic characterization of preterm infant gut microbiota development reveals species-specific metabolic shifts and variabilities during early life
BACKGROUND Establishment of the human gut microbiota begins at birth. This early-life microbiota development can impact host physiology during infancy and even across an entire life span. However, the functional stability and population structure of the gut microbiota during initial colonization remain poorly understood. Metaproteomics is an emerging technology for the large-scale characterizat...
متن کاملExternal Influence of Early Childhood Establishment of Gut Microbiota and Subsequent Health Implications
Postnatal maturation of immune regulation is largely driven by exposure to microbes. The gastrointestinal tract is the largest source of microbial exposure, as the human gut microbiome contains up to 10(14) bacteria, which is 10 times the number of cells in the human body. Several studies in recent years have shown differences in the composition of the gut microbiota in children who are exposed...
متن کاملInteractions of Respiratory Viruses and the Nasal Microbiota during the First Year of Life in Healthy Infants
Traditional culture techniques have shown that increased bacterial colonization is associated with viral colonization; however, the influence of viral colonization on the whole microbiota composition is less clear. We thus aimed to understand the interaction of viral infections and the nasal microbiota in early life to appraise their roles in disease development. Thirty-two healthy, unselected ...
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تاریخ انتشار 2016